A pilot study to examine the effects of cilostazol on post stroke cognitive impairment beyond stroke prevention and the prediction of cognitive change by macrophage polarization. Background: The antiplatelet drug cilostazol is efficacious for prevention of stroke recurrence compared with placebo. Cilostazol, a phosphodiesterase inhibitor, prevents no ... Protocol: Statin and dual antiplatelet therapy for the ... Background and purpose: The Cilostazol Stroke Prevention Study II has shown a similar efficacy in stroke prevention but markedly fewer hemorrhagic events with the phosphodiesterase inhibitor cilostazol versus aspirin. Systematic study of cilostazol on secondary stroke prevention: a meta-analysis Yining Qian and Qi Bi* Abstract Background: To study the efficacy and safety of cilostazol on ischemic stroke prevention and treatment, systematic reviews of related clinical randomized controlled trials … Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. stroke prevention. Abstract. In a cilostazol stroke prevention study to assess the safety and efficacy of cilostazol vs. aspirin, their effectiveness was observed to be similar with respect to the prevention of recurrent stroke in patients with noncardioembolic stroke; cilostazol was more efficacious and safer than aspirin for the prevention of secondary stroke. Patients receiving cilostazol together with aspirin or clopidogrel will be compared with those treated with aspirin or … We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention. HONOLULU – A combination of cilostazol and aspirin or clopidogrel reduces the risk of recurrent ischemic stroke, compared with aspirin or clopidogrel alone, among patients at high risk for recurrent stroke. In the CATHARSIS trial, the mean annual incidence of all vascular events, stroke, and ischaemic stroke tended to be lower in patients receiving dual therapy than in those receiving aspirin monotherapy. To the best of our knowledge, no randomised controlled trial of dual therapy with cilostazol plus thienopyridines for stroke has been done. OBJECTIVE Several reports have indicated that cilostazol is effective in the prevention of recurrence after cerebral infarction. 33,64,65 In CSPS, 1095 patients (65.6% men) who had a noncardioembolic stroke in the prior 1 18, article 53, 2013. Condition or disease. Conclusion: Based upon cumulative information from multiple clinical trials of secondary prevention of stroke, there is an increasing Background Stroke is one of the leading causes of death worldwide. 28/14,483 (20 ICH) 18 – 18: NR: NR: 13 supratentorial ICHs 7 infratentorial ICHs We designed CSPS 2 to establish non-inferiority of cilostazol compared with aspirin, and to assess the safety and efficacy of cilostazol compared with aspirin for prevention of stroke in patients with non-cardioembolic cerebral infarction. In this prospective, single-centre, open-label, non-randomised, single-arm, historically controlled study, we will compare early intensive treatment for BAD initiated within 24 hours of stroke onset, using DAPT (aspirin plus clopidogrel) and high-intensity statin treatment, with a historical control group of patients with BAD treated with single antiplatelet therapy, … BACKGROUND AND PURPOSE: Although dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the recurrence of ischemic stroke while significantly increasing the bleeding events compared with monotherapy, the CSPS.com trial (Cilostazol Stroke Prevention Study combination) showed that DAPT using cilostazol was more effective without the bleeding risk. trials, cilostazol signifi cantly improved symptoms of intermittent claudication in patients with peripheral artery disease.9 The TASC II international guideline recommends cilostazol as the fi rst-line drug for treatment of intermittent claudication.10 In the fi rst Cilostazol Stroke Prevention Study (CSPS) in 1052 patients in Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes. Clopidogrel, cilostazol, and aspirin were compared in terms of efficacy and safety for primary prevention of stroke in peripheral artery disease (PAD)… We hypothesized that the use of the PAS could improve the adherence to cilostazol in patients with chronic stroke. Cilostazol Stroke Prevention Study : A Placebo-controlled Double-blind Trial for Secondary Prevention of Cerebral Infarction. Cilostazol stroke prevention study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction. The purpose of this study is therefore to investigate how cilostazol affects cerebral hemodynamics and whether it prevents hemorrhagic transformation induced by … Study design. Table 2. Cerebral small vessel disease (SVD) causes 25% of ischemic stroke, most intracerebral hemorrhages, most vascular cognitive impairment and up to 45% of dementias, and other important aging-related comorbidities.1 There is no specific treatment to prevent SVD progression. MRC/BHF Heart protection study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo controlled trial. Cilostazol is a PDE3 (phosphodiesterase III) inhibitor with a long track record of safety that is Food and Drug Administration and European Medicines Agency approved for the treatment of claudication in patients with peripheral arterial disease. stroke prevention. A randomized trial by Shinichiro Uchiyama and team revealed that DAPT using cilostazol is superior to SAPT with clopidogrel or aspirin for the prevention of recurrent stroke and vascular events without increasing bleeding risk among patients with intracranial arterial stenosis after stroke. The CSPS.com is expected to provide evidence indicating whether secondary IS prevention in high-risk patients can be improved by using DAPT involving cilostazol. Fantastic result' with phosphodiesterase-3 inhibitor. 2000; 9: 147-157. 7 Primary ICH, 26 Secondary to HT of ischemic stroke: 17 (8–23) Long-term treatment prior to ICH: 7 on aspirin, 2 aspirin + clopidogrel, 1 on cilostazol, 1 clopidogrel ICH score median: 2 (range: 1–2)Mortality: 42.4% (14/33) Siegler et al. In the Cilostazol Stroke Prevention Study, a randomized double-blind, placebo-controlled trial involving more than 1000 Japanese patients, cilostazol was found to reduce the risk of secondary stroke by 41.7% compared with placebo, a statistically significant reduction (P = 0.015). We searched the main databases for eligible trials including literature from January 1966 to November 2012 in MEDLINE, reports from 1980 to November 2012 in EMBASE, and all the studies published … The second Cilostazol Stroke Prevention Study (CSPS 2) was designed to examine whether cilostazol was non-inferior to aspirin (at least … Huang Y, Cheng Y, Wu J, Li YX, Hong Z, Shang W, Ding M, Gao X, Fan D, 54. exp evaluation studies/ Zeng J, et al. According to the Cilostazol Stroke Prevention Study, patients with a prior stroke, who were allocated to cilostazol 100 mg twice daily or placebo, showed that cilostazol therapy reached a significant 58.3% reduction in ROCI, with no clinically significant adverse reactions . In patients with intracranial arterial stenosis, no significant increase in bleeding events was observed for DAPT with cilostazol and aspirin, compared to that for aspirin monotherapy. DAPT involving cilostazol may therefore be safer than conventional DAPT. This study is intended to demonstrate that the use of cilostazol plus nimodipine is safe and superior to nimodipine alone in the prevention of DCI in patients who have aSAH. The findings of the study are published in the Journal of the American Heart … This was achieved despite a reduction in major bleeding, as compared with aspirin. Methods Patients. The present study included patients with acute noncardioembolic ischemic stroke. In this prospective, single-centre, open-label, non-randomised, single-arm, historically controlled study, we will compare early intensive treatment for BAD initiated within 24 hours of stroke onset, using DAPT (aspirin plus clopidogrel) and high-intensity statin treatment, with a historical control group of patients with BAD treated with single antiplatelet therapy, … Background and purpose: The Cilostazol Stroke Prevention Study II has shown a similar efficacy in stroke prevention but markedly fewer hemorrhagic events with the phosphodiesterase inhibitor cilostazol versus aspirin. The new trial, the Cilostazol Stroke Prevention Study (CSPS) II, aimed to establish the noninferiority of cilostazol to aspirin for preventing recurrence of stroke, as well as evaluate safety-related events, in patients with noncardiogenic cerebral infarction. Background. Brief Summary: To examine the efficacy and safety of dual antiplatelet therapy (DAPT) including cilostazol (Pletaal OD Tablet ®) in comparison with antiplatelet monotherapy (excluding cilostazol) for secondary prevention of ischemic stroke in high-risk patients for stroke. Search PubMed; Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Dr. Fink reports no financial relationships relevant to this field of study. HONOLULU -- Stroke survivors taking dual antiplatelet therapy (DAPT) with the phosphodiesterase-3 inhibitor cilostazol (Pletaal) plus aspirin or clopidogrel (Plavix) for secondary prevention showed lower risk of recurrent stroke, relative to aspirin/clopidogrel monotherapy, with no trade-off in severe bleeding. 4. Sixth, for stroke prevention, cilostazol is advised to be taken at a dose of 200 mg/day. 3,4 Mechanism of action Google Scholar. cerebral infarction. Study design. The manufacturer-funded second Cilostazol Stroke Prevention Study (CSPS 2) was designed to establish clinical noninferiority of cilostazol versus aspirin for the prevention of recurrent stroke in patients with noncardioembolic stroke. Systematic study of cilostazol on secondary stroke prevention: a meta-analysis Yining Qian and Qi Bi* Abstract Background: To study the efficacy and safety of cilostazol on ischemic stroke prevention and treatment, systematic reviews of related clinical randomized controlled trials … The present pilot study investigated the efficacy and safety of cilostazol administration in the prevention of acute progressing stroke in patients with noncardioembolic infarction as a multicenter randomized controlled trial. Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. although follow-up was quite short. Future randomised trials can be conducted outside East Asia, or compare cilostazol with a wider range of antiplatelet agents. In the Cilostazol Stroke Prevention Study, a randomized double-blind, placebo-controlled trial involving more than 1000 Japanese patients, cilostazol was found to reduce the risk of secondary stroke by 41.7% compared with placebo, a … Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated that cilostazol is non-inferior, and might be superior to aspirin for prevention of stroke after an ischemic stroke . Forest plots of comparison of the incidence of ischemic stroke between cilostazol and aspirin groups in prevention and cure of ischemic stroke. One looked primarily at cilostazol as combination (cilostazol plus aspirin or clopidogrel) or monotherapy treatment compared to conventional single antiplatelet therapy for secondary stroke prevention. STUDY PROTOCOLS. 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